Progress in studies of glutathione S-transferase P1 and prostate cancer.
- Author:
Gao-feng HOU
1
;
Yong SUI
;
Li-wen AN
Author Information
1. Department of Urology, First Hospital, Heilongiiang University of Traditional Chinese Medicine, Harbin, Heilongjiang 150040, China.
- Publication Type:Journal Article
- MeSH:
Glutathione S-Transferase pi;
genetics;
Humans;
Male;
Prostatic Neoplasms;
diagnosis;
etiology
- From:
National Journal of Andrology
2006;12(12):1113-1115
- CountryChina
- Language:Chinese
-
Abstract:
Prostate cancer ( PCa) is an important genitourinary malignancy with increasing morbidity and mortality. Glutathione S-transferase P1 ( GSTP1) , as a phrase- II enzyme, has an important role in the activation and detoxification of carcinogens. There is a close association between GSTP1 gene polymorphisms and the risk of Pca. GSTP1 CpG island hypermethylation can reliably distinguish Pca from benign prostatic hyperplasia( BPH) and promises to be an important molecular marker for the diagnosis of Pca. This paper summarizes the association of GSTP1 with the diagnosis and risk of Pca.
