Detection of anti-Sp17 antibodies in infertile patients' serum and its clinical significance.
- Author:
Chun-hua ZHANG
1
;
Fang-qiu LI
;
Ai-long YANG
;
Wei SUN
;
Jia-wen MIAO
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Antigens, Surface; immunology; Autoantibodies; blood; Carrier Proteins; immunology; Contraception, Immunologic; Female; Humans; Infertility, Male; blood; immunology; Male; Spermatozoa; immunology
- From: National Journal of Andrology 2007;13(1):27-29
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo test anti-Sp17 antibodies in the serum of AsAb positive infertile patients, to investigate the proportion of anti-Spl7 antibodies in AsAb and their potential application to the serologic diagnosis of immune infertility and immunocontraception.
METHODSWith human recombinant Sp17 as the antigen, the ELISA method was used to detect the positive rate, antibody titre and content of anti-Sp17 antibodies in the AsAb positive serum.
RESULTSThe positive rate of anti-Sp17 antibodies in the AsAb positive serum was 56.5%, with no significant difference in the gender aspect. The percentage of anti-Sp17 antibodies in AsAb was (10.09 +/-7.45) %, with statistical significance (P <0.05).
CONCLUSIONSp17 is an important sperm antigen. Anti-Sp17 antibodies in the serum can be taken as auxiliary diagnostic index of infertility, and Sp17 is shown to be a potential candidate immunocontraception vaccine.
