Effects of Jujingwan on nitric oxide and superoxide dismutase in seminal plasma of asthenospermia patients.
- Author:
Bao-fang JIN
1
;
Xiao-yu YANG
;
Ting-song BIAN
;
Xiang ZHOU
;
Yu-feng HUANG
;
Xiu-lai WANG
;
Zuo-min ZHOU
;
Fu-song XU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Drugs, Chinese Herbal; pharmacology; therapeutic use; Humans; Male; Middle Aged; Nitric Oxide; metabolism; Oligospermia; drug therapy; metabolism; Phytotherapy; Semen; chemistry; Sperm Count; Sperm Motility; drug effects; Superoxide Dismutase; metabolism
- From: National Journal of Andrology 2007;13(1):87-90
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the possible action mechanism of Jujingwan on asthenospermia.
METHODSSemen routine analyses and determination of nitric oxide (NO) concentration and superoxide dismutase (SOD) activity in seminal plasma were performed in 34 cases of asthenospermia. The changes of NO concentration and SOD activity before and after the treatment with Jujingwan were observed.
RESULTSCompared with pre-treatment, there was no significant change in NO concentration, and the activity of SOD decreased significantly after the treatment ([95.97 +/- 20.75] microg/L vs [6.14 +/- 19.99] microg/L). There was negative correlation between NO concentration and SOD activity before the treatment (r = -0.246, P < 0.05).
CONCLUSIONJujingwan can significantly improve sperm viability in patients with asthenospermia. However, the excellent effects of Jujingwan are not displayed in the changes of NO concentration and SOD activity.
