The effect of oral carcinoma-associated fibroblasts on the invasion of carcinoma cell line.

Author: Jing-wen LIN ¹ ; Hong-mei ZHOU ; Sheng-fu LI ; Tao HU ; Qian-ming CHEN
Author Information

1. Key Laboratory of Oral Biomedical Engineering, Ministry of Education, Sichuan University, Chengdu 610041, China.
Publication Type:Journal Article
MeSH: Carcinoma, Squamous Cell; Cell Line; Cell Line, Tumor; Cell Proliferation; Fibroblasts; Humans; Mouth Neoplasms; Tongue Neoplasms
From: West China Journal of Stomatology 2006;24(2):101-103
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo observe the effect of oral carcinoma-associated fibroblasts (CAFs) on the invasion of a lingual carcinoma cell line, and to elucidate the role of CAFs in oral squamous cell carcinoma (OSCC) progression.
METHODSMatrigel was used to remodel the basement memberane, and the interaction model between primary oral CAFs and lingual carcinoma cell line Tca8113 was established by Transwell chamber to observe the effect of CAFs on the invasion of Tca8113.
RESULTSCompared with normal fibroblasts (NFs), CAFs promoted more Tca8113 cells to penetrate Matrigel (P < 0.05).
CONCLUSIONOral CAFs can promote the invasion of lingual carcinoma cell line Tca8113, and play a key role in OSCC progression.