Effects of mesenchymal stem cells transplantation on cranial suture distraction osteogenesis in growing goats.
- Author:
Qing-ran SHEN
1
;
Shu-juan ZOU
;
Yang-xi CHEN
;
Hai-xiao ZHOU
;
Jing HU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cranial Sutures; Goats; Mesenchymal Stem Cell Transplantation; Mesenchymal Stromal Cells; Osteogenesis, Distraction; Skull
- From: West China Journal of Stomatology 2006;24(2):153-155
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effects of mesenchymal stem cells (MSCs)on cranial suture under mechanical strain in growing goats.
METHODS10 growing goats were used in this study. A customized distractor was used for distraction of the coronal suture at a rate of 0.4 mm/day for 8 days. The experimental group(5 goats) was injected with autologous MSCs into the distracted region, whereas the control group (5 goats) with injection of physiological saline. All animals were killed at 4 weeks after the end of distraction. Scanning electron microscopy and histological analysis were taken to observe the samples.
RESULTS4 weeks after the end of distraction, the cranial sutures in all animals were separated successfully. The new bone formation at the edge of suture in the experimental group was superior to that in the control group.
CONCLUSIONAutologous MSCs transplantation may promote the cranial suture distraction osteogenesis in the growing goats.
