Clinical risk factors associated with the development of wheezing in children less than 2 years of age who required hospitalization for viral lower respiratory tract infections.
10.3345/kjp.2015.58.7.245
- Author:
Joon Hwan KIM
1
;
Ji Yeon CHOI
;
Na Yeon KIM
;
Jin Woo KIM
;
Ji Hyeon BAEK
;
Hye Sung BAEK
;
Jung Won YOON
;
Hye Mi JEE
;
Sun Hee CHOI
;
Hyeung Yoon KIM
;
Ki Eun KIM
;
Youn Ho SHIN
;
Man Yong HAN
Author Information
1. Department of Pediatrics, CHA Bundang Medical Center, Seongnam, Korea.
- Publication Type:Original Article
- Keywords:
Respiratory tract infections;
Risk factors;
Viruses;
Wheezing
- MeSH:
Asthma;
Child*;
Confounding Factors (Epidemiology);
Counseling;
Eosinophils;
Hospitalization*;
Humans;
Logistic Models;
Odds Ratio;
Parents;
Respiratory Sounds*;
Respiratory Tract Infections*;
Risk Factors*;
Tobacco Smoke Pollution
- From:Korean Journal of Pediatrics
2015;58(7):245-250
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Wheezing following viral lower respiratory tract infections (LRTIs) in children <2 years of age is an important risk factor for the development of asthma later in life; however, not all children with viral LRTIs develop wheezing. This study investigated risk factors for the development of wheezing during viral LRTIs requiring hospitalization. METHODS: The study included 142 children <2 years of age hospitalized for LRTIs with at least one virus identified as the cause and classified them into children diagnosed with LRTIs with wheezing (n=70) and those diagnosed with LRTIs without wheezing (n=72). RESULTS: There were no significant differences in the viruses detected between the two groups. Multivariate logistic regression analysis showed that, after adjusting for potentially confounding variables including sex and age, the development of wheezing was strongly associated with parental history of allergic diseases (adjusted odds ratio [aOR], 20.19; 95% confidence interval [CI], 3.22-126.48), past history of allergic diseases (aOR, 13.95; 95% CI, 1.34-145.06), past history of hospitalization for respiratory illnesses (aOR, 21.36; 95% CI, 3.77-120.88), exposure to secondhand smoke at home (aOR, 14.45; 95% CI, 4.74-44.07), and total eosinophil count (aOR, 1.01; 95% CI, 1.01-1.02). CONCLUSION: Past and parental history of allergic diseases, past history of hospitalization for respiratory illnesses, exposure to secondhand smoke at home, and total eosinophil count were closely associated with the development of wheezing in children <2 years of age who required hospitalization for viral LRTIs. Clinicians should take these factors into consideration when treating, counseling, and monitoring young children admitted for viral LRTIs.
