Expression of MMP-2 and MMP-3 in periodontal tissues of rat periodontitis model.

Author: Xiao-qin ZHAO ¹ ; Shu MENG ; Ya-fei WU ; Yu CHEN ; Song GE
Author Information

1. Key. Laboratory of Oral Biomedical Engineering Ministry of Education, Sichuan University, Chengdu 610041, China.
Publication Type:Journal Article
MeSH: Animals; Chronic Periodontitis; Fibroblasts; Gingivitis; Male; Matrix Metalloproteinase 2; Periodontal Ligament; Periodontitis; Rats
From: West China Journal of Stomatology 2006;24(3):202-205
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate the expression of MMP-2 and MMP-3 in periodontal tissues of rat periodontitis model at different stages of inflammation of varied severity.
METHODSThe periodontal tissues were immunohistochemically stained by antibody of MMP-2 and MMP-3.
RESULTSMMP-2 and MMP-3 were both strongly positive in gingival epithelia and fibroblasts in periodontal ligament in rat periodontitis model. And chronic periodontitis showed lower expression of MMP-2 and MMP-3 than that of acute gingivitis and acute peridontitis.
CONCLUSIONThe expression of MMP-2 and MMP-3 varies in different stage of periodontitis. MMP-2 and MMP-3 may play an important role in development of periodontitis.