Scutellarin starch microspheres' permeability through nasal mucosa of different animals in vitro.
- Author:
Shanghe YE
1
;
Xiaoling SONG
;
Changyu LI
;
Weihong GE
;
Senlin SHI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Apigenin; pharmacokinetics; Dogs; Glucuronates; pharmacokinetics; Microspheres; Nasal Mucosa; metabolism; Permeability; Starch; pharmacokinetics; Swine; Swine, Miniature
- From: China Journal of Chinese Materia Medica 2012;37(5):663-666
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study scutellarin starch microspheres' permeability through nasal mucosa of different animals in vitro.
METHODThe Franz diffusion cell method was used to experiment the permeability test (n = 4), taking fresh nasal mucosa of dog, swine and domestica in vitro as permeation barrier separately, with scutellarin starch microspheres (scutellarin 0.25 mg) above them, and blank pH 6.8 PBS as absorption liquid to detemine the scutellarin by HPLC.
RESULTThe permeability coefficient of scutellarin starch microspheres through nasal mucosa of dog, swine and domestica in vitro were (5.295 +/- 0.637) x 10(-3) (4.065 +/- 1.140) x 10(-3), (1.855 +/- 0.150) x 10(-3) cm x mL(-1) separately. The permeability coefficient order of scutellarin starch microspheres through nasal mucosa of different animals in vitro is dog > swine > domestica, and there are significant differences between the permeability coefficient of scutellarin starch microspheres through nasal mucosa of dog, swine in vitro, and that through nasal mucosa of swine and domestica in vitro.
CONCLUSIONDrugs in scutellarin starch microspheres could permeate through the above-mentioned nasal mucosa in vitro. There might be different permeability coefficient among different species.
