Comparison of effects of badu shengji san on rats with different injured skins.
- Author:
Yanli LU
1
;
Rong HE
;
Bo PENG
;
Qihua XU
;
Xuhui ZHANG
;
Han LIN
;
Jianrong LI
Author Information
- Publication Type:Journal Article
- MeSH: Acetylglucosaminidase; urine; Animals; Disease Models, Animal; Drugs, Chinese Herbal; pharmacology; therapeutic use; toxicity; Epithelial Cells; drug effects; metabolism; pathology; Kidney Tubules; drug effects; metabolism; pathology; Male; Mercury; toxicity; urine; Random Allocation; Rats; Rats, Sprague-Dawley; Retinol-Binding Proteins; urine; Skin; drug effects; injuries; Skin Ulcer; drug therapy; microbiology; Staphylococcal Skin Infections; drug therapy
- From: China Journal of Chinese Materia Medica 2012;37(6):711-714
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo compare the effects of Badu Shengji San (BDSJS) on rats with different injured skins.
METHODThe injured and ulcerous skin rat model was established to observe the renal injury induced by BDSJS, a mercury-containing external preparation of Chinese medicine, with urinary N-acetyl-beta-D-glucosaminidase (NAG) and retinol binding protein (RBP) as indicators of renal toxicity.
RESULTCompared to injured skin rats with the same dose, both of high and low-dose ulcerous skin groups showed obvious increase in urinary RBP and kidney coefficients, significant pathomorphological changes in renal tubules and notable epithelial cytopathic effects. In terms of NAG, the high-dose ulcerous skin group saw no significant increase, but the low-dose group recorded sharp rise.
CONCLUSIONThe renal toxicity induced by BDSJS in ulcerous skin rats was more toxic than that in injured skin ones.
