Effects of long-term external use of goupi gao on renal functions and lead accumulation in rats.
- Author:
Yong ZENG
1
;
Fanfan LI
;
Chungang LI
;
Huaibin CHEN
;
Guiqin ZHAO
;
Xianli MENG
Author Information
- Publication Type:Journal Article
- MeSH: Acetylglucosaminidase; urine; Animals; Blood Urea Nitrogen; Creatinine; blood; Drugs, Chinese Herbal; administration & dosage; toxicity; Female; Kidney; drug effects; metabolism; pathology; Lead; analysis; metabolism; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Spectrophotometry, Atomic; beta 2-Microglobulin; urine
- From: China Journal of Chinese Materia Medica 2012;37(6):731-734
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effect of long-term external use of Goupi Gao on renal function and lead accumulation in rats.
METHODRats were externally administered with Goupi Gao at different doses (7, 3.5 and 1.75 g x kg(-1)) for 90 d. At 45 days and 90 days after administration, the renal indicator, levels of blood urea nitrogen (BU) and creatinine (Cr) in serum, beta2-microglobulin (beta2-MG) and N-acetyl-beta-D-glucosaminidase (NAG) in urine were determined. Lead content in kidneys was detected by atomic absorption spectrometry.
RESULTA 90-day administration with Goupi Gao significantly enhanced the renal indicator, levels of NAG in urine and lead content in renal, when compared with the normal rats. However, the levels of BUN and beta2-MG as well as renal pathology in Goupi Gao treated rats were not obviously changed.
CONCLUSIONConsecutive administration of Goupi Gao for 90 days can increase the renal indicator and levels of NAG in urine, enhance the accumulation of lead in renal, but with no effect on excretory function of kidneys and organic changes.
