Comparative study on toxicity of Euphorbia before and after being prepared by vinegar.
- Author:
Yunying QIU
1
;
Hongli YU
;
Hao WU
;
Fagen ZHU
;
Wenting TAO
;
Qiuxiang XU
Author Information
- Publication Type:Journal Article
- MeSH: Acetic Acid; chemistry; Animals; Drugs, Chinese Herbal; chemistry; pharmacology; toxicity; Euphorbia; chemistry; toxicity; Female; Intestine, Small; drug effects; metabolism; Macrophages, Peritoneal; drug effects; metabolism; Male; Medicine, Chinese Traditional; Mice; Mice, Inbred ICR; Nitric Oxide; analysis; metabolism; Plant Roots; chemistry; toxicity; Toxicity Tests
- From: China Journal of Chinese Materia Medica 2012;37(6):796-799
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study and compare the changes of toxicity of Euphorbia pekinensis, E. kansui and E. ebracteolata before and after being prepared by vinegar.
METHODSmall intestinal accentuation of mice and peritoneal macrophage NO release experiments were assessed to investigate the changes of toxicity of the three Chinese Medicines of Euphorbia before and after being prepared.
RESULTE. pekinensis, E. kansui and E. ebracteolata and vinegar can obviously promot small intestinal accentuation and peritoneal macrophage NO release with the intensity of toxicity in the order of E. kansui > E. pekinensis > E. ebracteolata. After being prepared with vinegar, the toxicity of the three medicines decreased obviously compared to crude one.
CONCLUSIONE. pekinensis, E. kansui and E. ebracteolata can induce inflammation and accelerate enterokinesis. After being prepared with vinegar, the irritation on Euphorbia decreased obviously.
