Hydrolytic property and solution stability of NAMI derivative containing nicotinamide.
- Author:
Yaohu LIANG
1
;
Wei BI
;
Han YAN
;
Guogang LIANG
Author Information
- Publication Type:Journal Article
- MeSH: Dimethyl Sulfoxide; chemistry; Drug Stability; Hydrolysis; Imidazoles; chemistry; Kinetics; Ligands; Niacinamide; chemistry; Ruthenium; chemistry; Solutions; chemistry
- From: China Journal of Chinese Materia Medica 2012;37(6):818-823
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the influence of ligand structure on hydrolysis and solution stability of NAMI derivatives.
METHODNAMI type compound 1, trans- [RuCl4 (DMSO) (nica)] Na x 2DMSO (nica, nicotinamide) were prepared. Their hydrolytic mechanism, kinetics and stability were investigated by UV-Vis spectrophotometer.
RESULTSimilar to NAMI, compound 1 undergoes two well-separated steps chloro-hydrolysis (I chloro-hydrolysis and II chloro-hydrolysis) (step reaction) in pH 7.4 buffer solution; while dimethyl sulfoxide (DMSO) hydrolyze in pH 5.00 acetic buffer solution. The k(obs) and t1/2 for each hydrolytic reaction were determined.
CONCLUSIONThe stability of compound 1 in acidic solution is much more stable than that of in neutral solution. Nicotinamide in place of imidazole can decrease chloro hydrolytic rate of NAMI derivatives obviously, while the influence on the DMSO hydrolytic process is not so remarkable.
