New idea of traditional Chinese medicine quality control based on "composition structure" theory.
- Author:
Dan LIU
1
;
Xiaobin JIA
;
Danhong YU
Author Information
1. School of Pharmacy, Jiangsu University, Zhenjiang 212013, China. liudan0513@yeah.net
- Publication Type:Journal Article
- MeSH:
China;
Drug Therapy, Combination;
standards;
Drugs, Chinese Herbal;
standards;
therapeutic use;
Humans;
Medicine, Chinese Traditional;
standards;
Phytotherapy;
standards;
Quality Control
- From:
China Journal of Chinese Materia Medica
2012;37(6):865-870
- CountryChina
- Language:Chinese
-
Abstract:
On the road of the modern Chinese medicine developing internationally, there is a key issues that setting up a reasonable, accurate and be quantified quality evaluation system which is comply with the basic theory of Chinese medicine. Based on the overall understanding of the role of traditional Chinese medicine components, author suggested that the idea of "structural components" theory should be embedded into the system and thought the Chinese medicine play a multi-target, multi-channel pharmacodynamic effects founded on the specific microcosmic structural relationship between the components and the components within the group. At present, the way of Chinese pharmacopoeia checking the quality of Chinese medicine is mainly depends on controlling the single or multiple targets of ingredients. In fact, this way is out of the overall effectiveness of the Chinese medicine, so we can not thoroughly controlling the quality of Chinese medicine from the essence of the Chinese medicine. Secondly, it's only macro-structural quantity that the Chinese pharmacopoeia just controlling the less effective ingredients, this is not enough to reflect the internal microstructure of the integrity and systematic. In other words, this cannot reflect the structural components of the Chinese medicine (the essence of traditional Chinese medicine). In view of above mentioned reasons, the author propose the new idea on the quality control in the medicine that quantify the ratio structural relationship in component and the ingredients of the components, set the optimal controlling proportion between the components and ingredients. At the same time, author thought we should conduct the depth study in the micro-quantified the multi-component and multi-ingredient, in the process of studying the material basis of Chinese medicine. Therefore, it could establish a more rational basis for the Chinese medicine quality controlling system.
