Study about target-network of anti-cerebral infarction neuropathy based on theory of neurovascular unit and network pharmacology.
- Author:
Qingshan LIU
1
;
Liang FANG
;
Weiqun WANG
;
Ziqian ZHANG
;
Hongjun YANG
Author Information
- Publication Type:Journal Article
- MeSH: Calcium; metabolism; Caspases; metabolism; Cerebral Infarction; metabolism; prevention & control; Drug Delivery Systems; methods; Humans; MAP Kinase Signaling System; Matrix Metalloproteinases; metabolism; Medicine, Chinese Traditional; methods; Models, Biological; Pharmacology; methods; Phosphatidylinositol 3-Kinases; metabolism; Polyneuropathies; metabolism; prevention & control; Proto-Oncogene Proteins c-akt; metabolism; Signal Transduction
- From: China Journal of Chinese Materia Medica 2012;37(2):138-141
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEPotention drug-targets on anti-neuropathy of stroke were summarized, and it will provide materials for developing innovation components traditional Chinese medicine on anti-cerebral infarction neuropathy.
METHODThis article had done a series of researching work about neurovascular unit which includes three kinds of cells: neuron, gliacyte,brain microvascular endothelial cell, then signal mechanism of cell death or apoptosis of each section of stroke neuropathy was analysised by the historical documents.
RESULTThere are five important pathways: inflammatory factor-MMPs pathway- Caspases, Ca2+ -mitochondrial pathway-Caspases, Ca2+ -Phospholipase-PI-3K/AK pathway, Ca2+ -radical-MAPK pathway, Ca2+ -NO-protease pathway, among all the nodes, Caspases, Ca2+, NO were the most important ones.
CONCLUSIONDeveloping the multi-mechanism and multilevel of traditional chinese medicine under the guidance of the theories of network pharmacology and neurovascular unit will play an important role in studying the key links of signal-network of stroke neuropathy.
