Thoughts and exploration on studying pharmacological mechanism of traditional Chinese medicine using network biology approach.
- Author:
Zheng XIANG
1
;
Xianqin WANG
;
Ting LIU
;
Dan LV
Author Information
1. School of Pharmacy, Wenzhou Medical College, Wenzhou 325035, China. xzh007@126.com
- Publication Type:Journal Article
- MeSH:
Algorithms;
Drug Therapy;
methods;
Drugs, Chinese Herbal;
administration & dosage;
pharmacology;
therapeutic use;
Gene Regulatory Networks;
drug effects;
Humans;
Medicine, Chinese Traditional;
methods;
Metabolic Networks and Pathways;
drug effects;
Models, Biological;
Proteins;
genetics;
metabolism;
Signal Transduction;
drug effects
- From:
China Journal of Chinese Materia Medica
2012;37(2):146-151
- CountryChina
- Language:Chinese
-
Abstract:
The mechanism of synergetic effects of multi-components on multi-targets in traditional Chinese medicine (TCM) is one of the bottlenecks for TCM modernization and internationalization. Network biology approach was developed in recent years and provided an important and novel idea to study the pharmacological mechanism of TCM. This review introduced the mathematical basis of network biology, as well as the feasibility and research idea of using network biology to study the pharmacological mechanism of TCM. Network biology was expected to be further used for analyzing the pharmacological mechanism of TCM, guiding drug development of TCM, inheriting and carrying forward the fundamental principle of TCM.
