Determination of plasma protein binding rate of isopropylidene-shikimic acid.
- Author:
Hui KONG
1
;
Hongxia XING
;
Jin LIU
;
Lei YAN
;
Longfei LIN
;
Jian NI
Author Information
- Publication Type:Journal Article
- MeSH: Alkenes; chemistry; Animals; Blood Proteins; metabolism; Chromatography, High Pressure Liquid; Dogs; Humans; Protein Binding; Shikimic Acid; chemistry; metabolism; Species Specificity
- From: China Journal of Chinese Materia Medica 2012;37(2):255-257
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the plasma protein binding rate of isopropylidene-shikimic acid.
METHODThe ultrafiltration was employed to determine the plasma protein binding rate of isopropylidene-shikimic acid. The plasma concentrations of isopropylidene-shikimic acid were measured by HPLC.
RESULTThe plasma protein binding rate of isopropylidene-shikimic acid with dog plasma at the concentration of 0.3, 0.15 g x L(-1) and 0.5 mg x L(-1) were (4.36 +/- 0.02)%, (4.12 +/- 0.19)% and (2.23 +/- 0.59)%, respectively. While the plasma protein binding rate of isopropylidene-shikimic acid with normal human plasma at the above concentrations were (11.23 +/- 0.01)%, (10.06 +/- 0.69)% and (9.72 +/- 0.59)%, respectively.
CONCLUSIONThe binding rate of isopropylidene-shikimic acid with plasma protein is low.
