Pharmacokinetics effect of shaoyao gancao compound with different decocting methods on characteristic ingredients in rat plasma after oral administration.
- Author:
Lan SHEN
1
;
Rongwan HU
;
Xiao LIN
;
Yanlong HONG
;
Yi FENG
;
Desheng XU
;
Kefeng RUAN
Author Information
- Publication Type:Journal Article
- MeSH: Administration, Oral; Animals; Biological Availability; Chromatography, High Pressure Liquid; Drug Compounding; methods; Drugs, Chinese Herbal; administration & dosage; analysis; pharmacokinetics; Male; Paeonia; chemistry; Plasma; chemistry; Rats; Rats, Sprague-Dawley
- From: China Journal of Chinese Materia Medica 2012;37(1):52-56
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the pharmacokinetic effect of Shaoyao Gancao compound on rats using different decocting methods, and to pharmacokinetically detect the the compatibility of the component compounds of the Shaoyao Gancao compound from the pharmacokinetic viewpoint.
METHODBased on the established HPLC analytical method of plasma effective constituents, rats were orally administered with a single or mixed decoction of Shaoyao and Gancao. Blood at different times after administering these decoctions were collected, and then variance analysis was made for pharmacokinetic parameters.
RESULTThe results of all six rats indicated that the absorption of the mixed decoction of Shaoyao and Gancao was greater than that of the single decoction. While, the absorption of the characteristic peaks at the retention time of 5.2, 11.0, 12.0, 14.6 min had statistical significance.
CONCLUSIONShaoyao Gancao compound was proved better than that of the single decoction from the pharmacokinetic viewpoint.
