Security evaluation of bupivacaine, ropivacaine combined with fentanyl in postoperative continuous epidural analgesia.
- Author:
Xiao-hong WAN
1
;
Qing-qing HUANG
;
Mei-xian SU
;
Lin-jun WAN
;
Hai-qiong HUANG
Author Information
- Publication Type:Clinical Trial
- MeSH: Adolescent; Adult; Aged; Aged, 80 and over; Amides; administration & dosage; adverse effects; Analgesia, Epidural; adverse effects; methods; Analgesia, Obstetrical; adverse effects; methods; Analgesics, Opioid; administration & dosage; adverse effects; Anesthetics, Local; administration & dosage; adverse effects; Bupivacaine; administration & dosage; adverse effects; Female; Fentanyl; administration & dosage; adverse effects; Humans; Male; Middle Aged; Pain, Postoperative; prevention & control; Retrospective Studies
- From: Chinese Journal of Surgery 2006;44(17):1200-1202
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effects, side-effects and security of bupivacaine, ropivacaine combined with fentanyl in postoperative continuous epidural analgesia.
METHODSA total of 1 600 postoperative continuous epidural analgesia patients receiving different agents in SICU were divided into two groups: 0.1% bupivacaine +5 microg/ml fentanyl group (group B, n = 920) and 0.2% ropivacaine +2 microg/ml fentanyl group (group R, n = 680). The effects (visual analog-scale score and content to analgesia), side effects were analyzed retrospectively in the two groups.
RESULTSCompared with group B, patients in group R had higher analgesia contentment (P < 0.05), but no difference in visual analog-scale score was found in the two groups. The incidences of urinary retention, nausea and vomiting, skin itching in group B were significantly higher than those in group R (P < 0.05). In each group, patients over sixty had higher ratio of hypotension than those under sixty (P < 0.05); The female patients had a higher incidence of nausea and vomiting than male patients (P < 0.05); The incidence of debility and numbness of lower limbs in patients with lumbar segments epidural analgesia was higher than those with thoracic analgesia (P < 0.05).
CONCLUSIONS0.1% bupivacaine +5 microg/ml fentanyl and 0.2% ropivacaine +2 microg/ml fentanyl can provide adequate pain relief in postoperative continuous epidural analgesia, and 0.2% ropivacaine +2 microg/ml fentanyl comes with less side effects. The incidence of complication is related with analgesics, age, gender and the position of epidural puncture.