Therapeutic effects of early administration of low-dose heparin in patients with severe sepsis.
- Author:
Xiao-juan ZHANG
1
;
Xiao-chun MA
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Anticoagulants; administration & dosage; Combined Modality Therapy; Female; Heparin; administration & dosage; Humans; Injections, Intravenous; Male; Middle Aged; Sepsis; drug therapy; mortality; therapy; Survival Rate; Treatment Outcome
- From: Chinese Journal of Surgery 2006;44(17):1209-1211
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the therapeutic effects of early administration of low-dose heparin in patients with severe sepsis.
METHODSTwenty-two patients were randomly divided into experimental group and control group. In addition to the routine treatment, the patients in experimental group were given low-dose heparin, while those in control group were not. Prothrombin time (PT), activated partial thromboplastin time (APTT), platelet count, APACHE II score, ICU days, hospital days, cure rate, and 28-day survival rate were investigated in the two groups.
RESULTSAfter the treatment, PT and APTT recovered normal in the experimental group, but remained abnormal in the control group. There was no significant difference in platelet count between the two groups. ICU days in experimental group was shorter than that in control group (P < 0.01). Cure rate in experimental group was 81.8%, which was significantly higher than that in control group (54.5%). There was no significant difference in hospital days and 28-day survival rate between the two groups.
CONCLUSIONSEarly administration of low-dose heparin therapy can improve coagulative function in patients with severe sepsis, however, the survival rate was not improved.
