Association between vascular endothelial growth factor gene 936 T/C polymorphism and colorectal cancer together with anastomotic leakage.
- Author:
Guo-Yang WU
1
;
Xiao-Min WANG
;
Michael KEESE
;
Till HASENBERG
;
Jörg W STURM
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Alleles; Colorectal Neoplasms; genetics; surgery; Digestive System Fistula; etiology; genetics; Endothelial Growth Factors; genetics; Female; Gene Frequency; Genotype; Humans; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Postoperative Complications; etiology; Surgical Stomas; adverse effects
- From: Chinese Journal of Surgery 2006;44(21):1505-1507
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association between VEGF gene 936 T/C polymorphism and colorectal cancer together with anastomotic leakage.
METHODSPolymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the VEGF 936 T/C genotypes in colorectal cancer patients and healthy controls.
RESULTSThere was no significant difference in the frequency of VEGF 936 C/C genotype or C allele between colorectal cancer patients and healthy controls (P > 0.05). The C/C genotype or C allele in colorectal cancer patients with anastomotic leakage was less frequently found than in the group without anastomotic leakage (P < 0.05).
CONCLUSIONSVEGF 936 C/C genotype or C allele is not related to the development of colorectal cancer, but they can reduce the risk of anastomotic leakage after surgery in colorectal cancer patients.
