Effects of di'ao xinxuekang soft capsule on lipid peroxidation and the endothelial function in patients with coronary heart disease.
- Author:
Zheng-Long WANG
1
;
Bei SHI
;
Zhi-Jiang LIU
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Coronary Disease; drug therapy; metabolism; Drugs, Chinese Herbal; therapeutic use; Endothelins; blood; Endothelium, Vascular; physiopathology; Female; Humans; Lipid Peroxidation; Male; Malondialdehyde; blood; Middle Aged; Nitric Oxide; blood; Phytotherapy; Superoxide Dismutase; blood
- From: Chinese Journal of Integrated Traditional and Western Medicine 2012;32(6):782-784
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effects of Di' ao Xinxuekang Soft Capsule (DK) on the plasma levels of superoxide dismutase (SOD), malondialdehyde (MDA), nitric oxide (NO), and endothelin (ET) in patients with coronary heart disease (CHD), and to study its underlying mechanisms.
METHODSTotally 100 patients with CHD confirmed by coronary angiography were randomly assigned to two groups, the control group (60 cases) and the DK treatment group (40 cases). Patients in the control group received conventional therapy, while those in the DK treatment group received DK additionally. The therapeutic course for all was 3 months. The plasma levels of SOD, MDA, ET, and NO were determined pre-treatment, 4, 8, and 12 weeks after treatment.
RESULTSCompared with before treatment, the serum levels of SOD and NO increased and the levels of MDA and ET decreased at each time point. Besides, better effects were obtained in the DK treatment group (P < 0.05).
CONCLUSIONDK possibly played a role in inhibiting lipid peroxidation and improving the endothelial dysfunction.
