Synergistic interaction between MMP-3, VDR gene polymorphisms and occupational risk factors on lumbar disc degeneration.
- Author:
Han-Yan YUAN
1
;
Ying TANG
;
Ling LEI
;
Guo-Bing XIAO
;
You-Xin LIANG
;
Sheng WANG
;
Zhao-Lin XIA
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Case-Control Studies; Female; Humans; Intervertebral Disc Degeneration; genetics; pathology; Male; Matrix Metalloproteinase 3; genetics; Middle Aged; Occupational Exposure; Polymorphism, Single Nucleotide; Receptors, Calcitriol; genetics; Risk Factors
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2010;28(5):334-338
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the synergistic interaction between MMP-3,VDR gene polymorphisms and occupational risk factors on lumbar disc degeneration.
METHODSA case-control study including 178 cases of lumbar disc degeneration and 284 controls was carried out through questionnaire and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technology. Additive model was used to analyze the synergistic interaction between gene polymorphisms and occupational risk factors.
RESULTSThe non-conditional logistic regression analysis showed that bending/twisting, whole-body vibration, heavy physical workload, alleles 5A of MMP-3 (6A5A/5A5A) and A of VDR-Apa (AA/Aa) were significantly associated with lumbar disc degeneration(OR = 4.06, 8.96, 5.46, 1.96 and 1.70, respectively, P < 0.05). There were synergistic interactions between the mutation genotype 5A of MMP-3 and whole-body vibration exposure, between the mutation genotype 5A of MMP-3 and bending/twisting, and between the mutation genotype A of VDR-Apa and whole-body vibration exposure (SI: 13.27, 2.91 and 2.35 respectively, P < 0.05).
CONCLUSIONPeople with the mutation genotypes 5A of MMP-3 and/or A of VDR-Apa may have the increased risk of developing lumbar disc degeneration if they are exposed to whole-body vibration and/or bending/twisting.
