A Study of Antihypertensive Effect of Amlodipine.
10.4070/kcj.1991.21.6.1225
- Author:
Hyuck Moon KWON
;
Hyun Seung KIM
;
Yang Soo JANG
;
Sang Uk LIM
;
Eun Taek SIN
;
Kyung Chul KIM
;
Han Soo KIM
- Publication Type:Original Article
- Keywords:
Amlodipine;
Antihypertensive drug
- MeSH:
Amlodipine*;
Blood Pressure;
Calcium Channels;
Constipation;
Dizziness;
Dyspepsia;
Edema;
Flushing;
Headache;
Heart Rate;
Humans;
Skin;
Sleep Initiation and Maintenance Disorders
- From:Korean Circulation Journal
1991;21(6):1225-1230
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We evaluated the antihypertensive effect of amlodipine, a calcium channel bloker, in 35 cases of essential hypertention. After 12 weeks' administration(5~10mg q.d.), the following results were obtained : 1) The systoloic and diastolic blood pressure were decreased significantly(170.3+/-12.2mmHg vs 143.7+/-13.0mmHg p<0.01 and 104.7+/-5.9mmHg vs 87.8+/-6.5mmHg, p<0.01, respectively) but the heart rate was independant of amlodipine administration. 2) The systolic blood pressure was lowered by 20mmHg or more in 26(76.5%) of 34 patients and the diastolic pressure was lowered by 10mmHg or more in 26(76.5%) of 34 patients at 12 weeks after amlodipine administration. 3) The adverse effects of amlodipine were dizziness in 5, edema in 5, indigestion in 3, constipation in 2, headache, flushing, insomnia in 1 patient respectively and only one of them discontinued amlodipine administration due to severs facial flushing and skin eruption.
