Red blood cell on lymphocyte proliferation in rats with chronic unpredictable mild stress.
- Author:
Su-zhen GUAN
1
;
Yu-long LIAN
;
Ji-wen LIU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cell Proliferation; Depression; blood; etiology; Disease Models, Animal; Erythrocytes; cytology; Lymphocyte Activation; Lymphocytes; cytology; Male; Rats; Rats, Wistar; Stress, Psychological; physiopathology
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2010;28(6):423-426
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the changes of rat red blood cells on T, B lymphocytes proliferation in chronic unpredictable mild stress (CUMS).
METHODSThirty Wistar rats were averagely divided into control group and the CUMS group. The relevant behavioral performance and red blood cells on lymphocytes proliferation Changes by MTT colorimetric were observed.
RESULTSAfter fourteen days, the growth of weight and organic coefficient of brain decreased in model group (P < 0.05), with a significantly reduced consumption and preference of sucrose solutions, and increased pure water consumption as compared with control group (P < 0.05). Plasma corticosterone levels peaked at seven days but on a declining trend after fourteen days. The rate of red blood cells on T, B lymphocyte proliferation in depression group was lower than non-stress in 7, 14, 21 days (P < 0.05).
CONCLUSIONThe repeated chronic mild stress stimulation can induce long-time changes in acts and activities and decrease the rate of red blood cells on T, B lymphocytes proliferation, which can provide a new experimental method to observe the red blood cell immune function under the stress.
