Expression and prognostic significance of galectin-1 and galectin-3 in benign nevi and melanomas.

Zhong-wu LI; Yan Wang; Wei-cheng Xue; Lu SI; Chuan-liang Cui; Deng-feng Cao; Li-xin Zhou; Jun Guo; Ai-ping LU

Return

Expression and prognostic significance of galectin-1 and galectin-3 in benign nevi and melanomas.

Author: Zhong-wu LI ¹ ; Yan WANG ; Wei-cheng XUE ; Lu SI ; Chuan-liang CUI ; Deng-feng CAO ; Li-Xin ZHOU ; Jun GUO ; Ai-ping LU
Author Information

1. Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Pathology, Peking University Cancer Hospital and Institute, Beijing 100142, China. E-mail: zhwuli@hotmail.com.
Publication Type:Journal Article
MeSH: Adolescent; Adult; Aged; Aged, 80 and over; Child; Female; Galectin 1; metabolism; Galectin 3; metabolism; Humans; Immunohistochemistry; Liver Neoplasms; secondary; Lung Neoplasms; secondary; Lymphatic Metastasis; Male; Melanoma; metabolism; pathology; secondary; Middle Aged; Nasal Mucosa; metabolism; Neoplasm Staging; Nevus; metabolism; pathology; Skin Neoplasms; metabolism; pathology; Survival Rate; Young Adult
From: Chinese Journal of Pathology 2013;42(12):801-805
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo study the expression and prognostic significance of galectin-1 and galectin-3 in different melanocytic lesions.
METHODSThe expression of galectin-1 and galectin-3 in 39 cases of benign nevus, 58 cases of primary cutaneous melanoma, 24 cases of primary mucosal melanoma, 69 cases of melanoma with lymph node metastasis and 8 cases of melanoma with distant metastasis were studied by immunohistochemistry and tissue microarray.
RESULTSThe expression of galectin-1 and galectin-3 was higher in benign nevi than in melanomas (P < 0.01). The nuclear expression of galectin-3 was higher in primary cutaneous melanomas than in primary mucosal melanomas or melanomas with metastases (P < 0.01, respectively). The expression correlated with age of patients (P < 0.05), necrosis (P < 0.05) and survival time (P < 0.01). Clark's level also correlated with survival time in patients with cutaneous melanomas (P = 0.037). TNM staging was the only independent prognostic factor for melanomas (P < 0.01).
CONCLUSIONSThe expression of galectin-1 and galectin-3 is decreased in melanomas. The decrease in nuclear expression of galectin-3 may represent a poor prognostic factor for melanomas. TNM staging is an independent prognostic factor which influences the survival time.