Effects of Intravenous Magnesium Sulfate on the Prevention of Pain Following Injection of Microemulsion Propofol.
- Author:
Se Jin LEE
1
;
Soon Im KIM
;
Sun Young PARK
;
Mun Gyu KIM
;
Ho Bum CHO
;
Yoo Mi HAN
Author Information
1. Department of Anesthesiology and Pain Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea. alvesta@schmc.ac.kr
- Publication Type:Randomized Controlled Trial ; Original Article
- Keywords:
Aquafol;
Injections;
Lidocaine;
Magnesium;
Pain;
Propofol
- MeSH:
Adult;
Anesthesia, General;
Arm;
Blood Pressure;
Calcium Channels;
Heart Rate;
Humans;
Hypertension;
Incidence;
Lidocaine;
Magnesium Sulfate*;
Magnesium*;
N-Methylaspartate;
Propofol*;
Prospective Studies;
Shoulder;
Wrist
- From:Soonchunhyang Medical Science
2015;21(2):70-74
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: The aim of this study was to investigate the effects of intravenous magnesium sulfate on the prevention of pain during the injection of microemulsion propofol. Magnesium is a known calcium channel blocker and a physiological N-methyl-D-aspartate receptor antagonist. METHODS: American Society of Anesthesiologists I and II adults (n=114) undergoing general anesthesia for surgery were randomly assigned into two groups (n=57 per group). This study was designed in prospective and double-blind manner. Patients in the LM group (n=57) received pretreatment with 2% lidocaine (40 mg) and magnesium sulfate 10 mg/kg, while patients in group L (n=57) received pretreatment with 2% lidocaine (40 mg) and normal saline (2 mL) accompanied by venous occlusion. Induction with microemulsion propofol (Aquafol) 2 mg/kg was accomplished following the release of venous occlusion. Pain intensity was assessed on a four-point scale according to patient movement (grade 0, no movement; grade 1, movement in wrist only; grade 2, movement in the upper arm & shoulder of injected arm; grade 3, generalized movement). Systolic blood pressure, diastolic blood pressure, and heart rate were evaluated. RESULTS: A significant difference in pain intensity following injection of microemulsion propofol between the groups was found (P<0.05). In addition, the incidence of hypertension after injection was lower in the LM group than in the L group (P<0.05). CONCLUSION: The combination of magnesium and lidocaine are effective in attenuating the pain induced by microemulsion propofol injection when compared with lidocaine alone.
