Inadvertent Transmission of a Donor's Constitutional Chromosome Abnormality after Hematopoietic Stem Cell Transplantation.
- Author:
Jina YUN
1
;
Hyun Ho JO
;
Byung Ryul JEON
;
You Kyoung LEE
;
Chan Kyu KIM
;
Seong Kyu PARK
;
Dae Sik HONG
Author Information
1. Division of Hematology-Oncology, Department of Internal Medicine, Bucheon, Korea. skpark@schmc.ac.kr
- Publication Type:Case Report
- Keywords:
Hematopoietic stem cell transplantation;
Chromosome aberrations;
Leukemia
- MeSH:
Biopsy;
Bone Marrow;
Chromosome Aberrations*;
Consolidation Chemotherapy;
Cytogenetic Analysis;
Cytogenetics;
Hematopoietic Stem Cell Transplantation*;
Hematopoietic Stem Cells*;
Humans;
Induction Chemotherapy;
Leukemia;
Leukemia, Myeloid, Acute;
Male;
Mass Screening;
Middle Aged;
Siblings;
Stem Cells;
Tissue Donors;
Transplants
- From:Soonchunhyang Medical Science
2015;21(2):137-141
- CountryRepublic of Korea
- Language:English
-
Abstract:
A pre-transplant screening work-up of donors for allogeneic hematopoietic stem cell transplantation (HSCT) is essential. Inadvertent transmission of malignancy from donors with subclinical diseases to recipients has been reported recently in several cases. A 49-year-old male was diagnosed with acute myeloid leukemia. He underwent a course of induction chemotherapy and achieved cytogenetic complete remission (CR). He was treated with an additional cycle of consolidation chemotherapy followed by full matched sibling allogeneic HSCT due to an additional deletion in 9q known as an adverse prognostic factor. Post transplantation bone marrow biopsy revealed molecular CR, but conventional cytogenetics identified the presence of 46,XY,t(1:2)(p32:q35). A cytogenetic analysis of the donor graft specimen revealed t(1:2). We confirmed the donor origin of t(1:2). We report the first case of a person with constitutional t(1;2) serving as a stem cell donor.
