Transglutaminase and neurodegenerative diseases.
10.3760/cma.j.issn.1003-9406.2015.04.025
- Author:
Zhen LIU
1
;
Junsheng ZENG
;
Sheng ZENG
;
Beisha TANG
;
Junling WANG
Author Information
1. Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P. R. China. wjling8002@126.com.
- Publication Type:Journal Article
- MeSH:
Animals;
Brain;
enzymology;
Humans;
Neurodegenerative Diseases;
enzymology;
genetics;
Transglutaminases;
genetics;
metabolism
- From:
Chinese Journal of Medical Genetics
2015;32(4):562-566
- CountryChina
- Language:Chinese
-
Abstract:
Transglutaminase (TG) is a kind of calcium-dependent enzymes. The TGase family found in rodents and human contains 9 types, including TG1-7, blood coagulation factor XIIIa and erythrocyte membrane protein 4.2, with the former 8 types possessing catalytic activity. TG catalyzes various conversion reactions of glutamine, including transamination, deamination and esterification, and participates in post-transcriptional modification of proteins such as cross-linking peptides glutamine residue and lysyl-residue, stabilizing protein structure and catalyzing formation of protein aggregates. TGase has been found to contribute to a variety of important physiological and pathological processes and play a role in the pathogenesis of multiple diseases. Notably, neurodegenerative diseases such as Huntington's disease, spinocerebellar ataxia, Alzheimer's disease and Parkinson's disease, have a close connection with TGase's role in the human body.
