Advances in research of SCARB2 functions and related disorders.
10.3760/cma.j.issn.1003-9406.2015.05.025
- VernacularTitle:清道夫受体B2功能及相关疾病研究进展
- Author:
Miao HE
1
;
Zhen LIU
;
Beisha TANG
;
Junling WANG
Author Information
1. Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China. Email: wjling8002@126.com.
- Publication Type:Journal Article
- MeSH:
Hand, Foot and Mouth Disease;
genetics;
Humans;
Lysosome-Associated Membrane Glycoproteins;
chemistry;
genetics;
physiology;
Myoclonic Epilepsies, Progressive;
genetics;
Parkinson Disease;
genetics;
Receptors, Scavenger;
chemistry;
genetics;
physiology
- From:
Chinese Journal of Medical Genetics
2015;32(5):723-727
- CountryChina
- Language:Chinese
-
Abstract:
SCARB2 (scavenger receptor class B, member 2) is a lysosomal membrane glucoprotein, which is encoded by SCARB2 gene. It takes vital parts in the physiological and pathological processes including the transportation of beta-glucocerebrosidase to the lysosome, infection of EV71 and load-induced cardiac myocyte hypertrophy. This article has reviewed the molecular structure and functions of SCARB2 gene and its protein, as well as their relationship with diseases.
