Progress of molecular genetics research on rheumatoid arthritis.
10.3760/cma.j.issn.1003-9406.2015.05.026
- VernacularTitle:类风湿关节炎的分子遗传学研究进展
- Author:
Rong CHEN
1
;
Jiaming LUO
;
Dingding ZHANG
Author Information
1. Department of Microbiology and Immunology, North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China. Email: zdd25@sina.com.
- Publication Type:Journal Article
- MeSH:
Arthritis, Rheumatoid;
genetics;
Exome;
Genetic Predisposition to Disease;
HLA-DRB1 Chains;
genetics;
Hepatitis A Virus Cellular Receptor 2;
Humans;
Membrane Proteins;
genetics;
Protein Tyrosine Phosphatase, Non-Receptor Type 22;
genetics;
Receptors, IgG;
genetics
- From:
Chinese Journal of Medical Genetics
2015;32(5):728-733
- CountryChina
- Language:Chinese
-
Abstract:
Rheumatoid arthritis (RA) is a chronic, inflammatory, autoimmune disorder that principally attacks flexible joints and synovia. The precise pathogenesis of RA remains unclear, and genetic factors probably play an important role in its etiology. In addition to genes from human leukocyte antigen (HLA) region, such as HLA-DRB, genes from non-HLA region, such as TIM-3, PTPN22, TRAF1/C5, STAT4, CCR5, PADI4 and FCGR2A may also contribute to its susceptibility. The advance in molecular genetics research on RA is reviewed here.
