Chromosomal microarray analysis for lateral ventriculomegaly in fetus.
- VernacularTitle:胎儿侧脑室增宽的染色体微阵列分析
- Author:
Zhiqiang ZHANG
1
;
Yingjun XIE
;
Jianzhu WU
;
Xiaodan CHEN
;
Shaobin LIN
;
Yuanjun JI
;
Weiying JIANG
;
Qun FANG
;
Baojiang CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Chromosome Aberrations; Chromosome Deletion; Chromosome Duplication; Female; Gestational Age; Humans; Hydrocephalus; diagnosis; diagnostic imaging; genetics; Lateral Ventricles; abnormalities; diagnostic imaging; metabolism; Microarray Analysis; methods; Pregnancy; Reproducibility of Results; Sensitivity and Specificity; Ultrasonography, Prenatal; methods; Young Adult
- From: Chinese Journal of Medical Genetics 2015;32(6):789-792
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between fetal lateral ventriculomegaly and chromosomal microarray analysis (CMA) abnormalities.
METHODSFifty fetuses with lateral ventriculomegaly detected by ultrasound and a normal karyotype were included. Forty four fetuses were classified as mild ventriculomegaly (MVM), in which the lateral ventricular atrium was 10-15 mm. Six had severe ventriculomegaly (SVM), with the lateral ventricularatrium being ≥ 15 mm. The fetuses were also divided into isolated (n= 21) and non-isolated groups (n= 29) based on whether they are associated with other anomalies.
RESULTSThirteen (26%) of the fetuses were found to be abnormal by CMA. For the 44 cases with MVM, 9 (20.9% ) were found to be abnormal, while for the 6 cases with SMV, 4 (66.7%) were found to be abnormal (P>0.05). CMA abnormalities were found in 2 (9.5%) of the 21 fetuses with isolated ventriculomegaly group and 11 (37.9%) of the 29 fetuses with non-isolated ventriculomegaly group (P<0.05).
CONCLUSIONChromosome microdeletions and microduplications are the most common abnormalities found in fetal lateral ventriculomegaly. When ventriculomegaly is associated with other anomalies, the incidence of CMA abnormally is much higher. Prenatal diagnosis is necessary for fetuses with lateral ventriculomegaly.
