Association of rs13405728 polymorphism of LHR gene with slow ovarian response.
- Author:
Qianqian YIN
1
;
Yu LI
;
Jia HUANG
;
Dongzi YANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Female; Fertilization in Vitro; methods; Gene Frequency; Genotype; Humans; Logistic Models; Ovarian Reserve; genetics; Ovulation Induction; methods; Polymorphism, Single Nucleotide; Receptors, LH; genetics; Reproductive Techniques, Assisted; Sequence Analysis, DNA; methods
- From: Chinese Journal of Medical Genetics 2015;32(6):840-843
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the association of rs13405728 polymorphism of luteinizing hormone receptor (LHR) gene with slow ovarian response during assisted reproductive technology (ART).
METHODSTwo hundred and thirty-six women were enrolled and grouped according to their genotypes. The rs13405728 polymorphism was genotyped by DNA sequencing.
RESULTSNo signifiicant difference was found in antral follicle count and anti-Mullerian hormone between the three genotypes (P>0.05). The incidence of slow response in genotype GG was lower than in the other two genotypes (P<0.05). There was no significant difference in the amount of follicle stimulating hormone required, the number of follicles ≥14 mm on human chorionic gonadotrophin day, oocytes, mature oocytes, available embryos, and the clinical pregnancy rate among the three genotypes (P>0.05). There was an independent correlation between slow ovarian response with the genotypes of rs13405728, the initial dose of gonadotropin, and the dose of luteinizing hormone required (P<0.05).
CONCLUSIONRs13405728 of the LHR gene may be associated with slow ovarian response in ART. Various mechanisms may be involved in the poor response and slow response.
