Association of ADAMTS-1 gene polymorphisms with ischemic stroke caused by large artery atherosclerosis.
- Author:
Chenling LYU
1
;
Yawen CHEN
;
Min ZHU
;
Xiaoping JIN
;
Peng LIU
;
Zhou ZHENG
;
Cai LI
;
Feng ZHU
;
Xiaofei HU
;
Feng WANG
;
Weiling LI
;
Wanfeng WANG
Author Information
- Publication Type:Journal Article
- MeSH: ADAM Proteins; genetics; ADAMTS1 Protein; Aged; Alleles; Atherosclerosis; complications; Base Sequence; Blood Glucose; metabolism; Brain Ischemia; complications; Fasting; blood; Female; Gene Frequency; Genetic Predisposition to Disease; genetics; Genotype; Humans; Logistic Models; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Risk Factors; Sequence Analysis, DNA; Smoking; Stroke; blood; etiology; genetics
- From: Chinese Journal of Medical Genetics 2015;32(6):844-848
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the association of a disintegrin and metallo-proteinase with thrombospondin type 1 motifs (ADAMTS-1) gene polymorphism and ischemic stroke caused by large artery atherosclerosis (LAA).
METHODSIn total 767 patients and 506 controls were recruited. Single nucleotide polymorphisms (SNPs) rs416905 (T/C) and rs402007 (G/C) of the ADAMTS-1 gene were genotyped by polymerase chain reaction and DNA sequencing.
RESULTSFrequencies of the rs402007 GC+CC genotype and the C allele were significantly different between the two groups (68.84% vs. 60.67%, χ2=9.012, P=0.003, OR=1.432; 45.24% vs. 38.54%, χ2=11.208, P=0.001, OR=1.318). Binary logistic regression has confirmed that the above difference was significant (P=0.001, OR=1.521, 95%CI: 1.183-1.955). The frequencies of TC+CC and GC+CC genotypes were similar between the two groups, and so was it with the C allele. The two SNPs had been in complete linkage disequilibrium (D'=1.0, r2=1.0).
CONCLUSIONThe rs416905 and rs402007 polymorphisms of the ADAMTS-1 gene may be associated with ischemic stroke caused by LAA. The C allele of the rs402007 locus may be a susceptibility factor for this subtype of stroke.
