Effect of mitochondrial DNA 5178 C/A polymorphism on risks for type 2 diabetes mellitus and its complications.
- Author:
Xunjun YANG
1
;
Yuning ZHANG
;
Yin MA
;
Qiongya ZHAO
;
Jianxin LYU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Blood Glucose; metabolism; Cholesterol; blood; Cholesterol, HDL; blood; DNA, Mitochondrial; chemistry; genetics; Diabetes Complications; blood; genetics; Diabetes Mellitus, Type 2; blood; complications; genetics; Diabetic Nephropathies; blood; genetics; Fasting; blood; Female; Humans; Hypertension; blood; complications; genetics; Male; Meta-Analysis as Topic; Middle Aged; Odds Ratio; Polymorphism, Single Nucleotide; Sequence Analysis, DNA; Triglycerides; blood
- From: Chinese Journal of Medical Genetics 2015;32(6):855-860
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the role of mitochondrial DNA 5178 C/A (Mt5178) polymorphism of NADH-dehydrogenase subunit 2 (ND2) gene in type-2 diabetes mellitus (T2DM) among ethnic Han Chinese through a case-control study.
METHODSThe Mt5178C/A polymorphism was determined by sequencing 1103 T2DM patients and 791 healthy controls. Logistic regression analysis was conducted to estimate odds ratios (OR) and 95% confidence intervals (CI). To confirm the results, a meta-analysis was conducted based on published literature on the association of Mt5178 variant with T2DM.
RESULTSNo significant association was found between the Mt5178C/A variant and T2DM either by our study or the meta-analysis which included eight published studies. Nevertheless, it was found that the T2DM patients with 5178C genotype were at a higher risk for nephropathy complication (OR=1.49, 95%CI: 1.005-2.197, P<0.05) and at significantly lower risk for hypertension complication (OR=0.744, 95%CI: 0.556-0.996, P<0.05) compared with those carrying a 5178A genotype.
CONCLUSIONNo association was found between the Mt5178C/A polymorphism of mitochondrial ND2 gene with the increased risk of T2DM. However, the polymorphism may affect the development of nephropathy and hypertension complications among T2DM patients.
