Association of vitamin D receptor gene polymorphisms with mild cognitive impairment among elderly ethnic Uygurs.
- Author:
Xiaohui ZHOU
1
;
Meisheng ZHU
;
Li MA
;
Haijun MIAO
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Alleles; Asian Continental Ancestry Group; genetics; Binding Sites; genetics; Blood Pressure; China; Cognitive Dysfunction; ethnology; genetics; psychology; Deoxyribonucleases, Type II Site-Specific; metabolism; Diagnostic and Statistical Manual of Mental Disorders; Ethnic Groups; genetics; Female; Gene Frequency; Genetic Predisposition to Disease; ethnology; genetics; Genotype; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Polymorphism, Single Nucleotide; Receptors, Calcitriol; genetics; Triglycerides; blood
- From: Chinese Journal of Medical Genetics 2015;32(6):877-880
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the association of vitamin D receptor gene (VDR) Apa I, Bsm I genotypes and allele frequencies and mild cognitive impairment (MCI) among elderly ethnic Uygurs from Xinjiang, China.
METHODSThe polymorphisms of the VDR genotypes (Apa I and Bsm I) were analyzed by the SNaPshot method in 124 MCI patients and 124 controls.
RESULTSFactors which can increase the risk for MCI have included the A allele of the Apa I polymorphism [OR=1.62, 95%CI(1.13-2.31)] and the AA genotype [OR=3.49, 95% CI(1.57-7.74)], the T allele of the Bsm I polymorphism [OR=1.94, 95%CI(1.24-3.05)], higher triglyceride and systolic blood pressure levels.
CONCLUSIONPolymorphisms of the VDR gene including the A allele and AA genotype of Apa I, and the T allele of Bsm I are probably associated with MCI among elderly ethnic Uygurs, and so are higher levels of triglyceride and systolic blood pressure.
