Clinical significance of detecting t(11;14) by fluorescence in situ hybridization for the diagnosis of 7 patients with atypical mantle cell lymphoma.
- Author:
Jianfeng ZHU
1
;
Zhengdong WU
;
Lei FAN
;
Wei XU
;
Jianyong LI
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Chromosomes, Human, Pair 11; genetics; Chromosomes, Human, Pair 14; genetics; Female; Humans; In Situ Hybridization, Fluorescence; methods; Lymphoma, Mantle-Cell; diagnosis; genetics; Male; Middle Aged; Translocation, Genetic
- From: Chinese Journal of Medical Genetics 2016;33(1):13-16
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the clinical features and diagnosis of 7 patients with atypical mantle cell lymphoma (MCL).
METHODSThe 7 MCL patients were misdiagnosed as chronic lymphocytic leukemia (CLL) due to a score of 4 for their immunophenotypes. The clinical features and diagnosis of such patients were retrospectively analyzed.
RESULTSSix patients had superficial lymphadenectasis but their lymph nodes could not be palpated. All 7 patients were as stage IV considering bone marrow infiltration. Scores of immunophenotype of CLL were 4, and interphase fluorescence in situ hybridization (FISH) for t(11;14) were positive in all patients.
CONCLUSIONSome MCL patients have clinical features similar to CLL. Interphase FISH can play an important role in the diagnosis of MCL.
