Influence of match-pair of huanglian-rougui on rat intestinal absorption of total huanglian alkali.
- Author:
Yu-jie ZHANG
1
;
Jie YANG
;
Xiao-cui ZOU
;
Li-mei LIU
;
Wan-jing SUN
Author Information
- Publication Type:Journal Article
- MeSH: Alkaloids; isolation & purification; pharmacokinetics; Animals; Biological Transport; drug effects; Cinnamomum; chemistry; Coptis; chemistry; Drugs, Chinese Herbal; isolation & purification; pharmacology; Intestinal Absorption; drug effects; Intestinal Mucosa; metabolism; Male; Matched-Pair Analysis; Plants, Medicinal; chemistry; Rats; Rats, Sprague-Dawley
- From: China Journal of Chinese Materia Medica 2007;32(15):1521-1524
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo research the principle of match-pair of huanglian-rougui.
METHODA rat intestinal model in vitro had been applied to investigate the absorption and transport characteristics of total huanglian alkali across intestinal mucosa, as well as the influence of match-pair of huanglian-rougui on its intestinal absorption. The identification of alkalis in primitive solution, serosal solution and intestinal homogenate were analyzed by TLC.
RESULTThe transport and uptake characteristic of total alkali in huanglian solution was similar to berberine. The uptake and transport of total alkali across intestinal mucosa was concentration-and time-dependent. Transport directions had strong effects on the transport of total alkali. The amount of total alkali transport from serosal side to mucosal side was much more than that from mucosal side to serosal side. After matching with rougui as some ration, the intestinal absorption of total alkali increased significantly comparing with huanglian alone, and there was an optimal ration among match-pair of huanglian-rougui.
CONCLUSIONChemical reaction in vitro and intestinal absorption were the key factors of match-pair of huanglian-rougui.
