Preparation of kangfuxin colon targeting micro-pellets.
- Author:
Ming YANG
1
;
Xue-lan QIU
;
Xing-liang XIE
;
Juan LAI
;
Si-wei CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Colon; metabolism; Delayed-Action Preparations; Drug Carriers; Drug Compounding; methods; Drug Delivery Systems; Hydrogen-Ion Concentration; Hypromellose Derivatives; Materia Medica; administration & dosage; isolation & purification; metabolism; Methylcellulose; analogs & derivatives; Pectins; Periplaneta; chemistry; Polymethacrylic Acids
- From: China Journal of Chinese Materia Medica 2007;32(15):1529-1532
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo prepare coated micro-pellets of pH-dependent and enzyme-dependent kangfuxin colon targeting delivery system, to make them go to colon, then release, educe partial effect.
METHODWe eploy pan-pill to prepare simple pellets, and prepare tunicatus pellets with fluidized bed coating. We investigated the preparation and parameter of pellets, so, we bolting the best shaping and tunicatus artwork.
RESULTThe ingredients for preparing the micro-pellets are 125% starch +2% CMC-Na, and add 30% ethanol to be binder, pellets were coated with Eudragit S100 to prepare ph-dependent and pectin-HPMC to prepare enzyme-dependent colon targeting micro-pellets.
CONCLUSIONWe get two micro-pellets of pH-dependent and enzyme-dependent kangfuxin colon targeting.
