Effects of kaixinsan on behavior and expression of p-CREB in hippocampus of chronic stress rats.
- Author:
Jin-liang WANG
1
;
Ping LIU
;
Hai-hua TU
;
Zhong-xiao WANG
;
Gui-yun CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antidepressive Agents; pharmacology; Behavior, Animal; drug effects; Cyclic AMP Response Element-Binding Protein; metabolism; Depression; etiology; physiopathology; Drug Combinations; Drugs, Chinese Herbal; isolation & purification; pharmacology; Hippocampus; metabolism; Male; Plants, Medicinal; chemistry; Random Allocation; Rats; Rats, Wistar; Stress, Psychological; complications
- From: China Journal of Chinese Materia Medica 2007;32(15):1555-1558
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effects of kaixinsan on behavior and expression of p-CREB in hippocampus of the chronic stress rats.
METHODThe male Wistar rats which gained the similar scores by Open-field test were selected, then the depression model rat was produced by separation and chronic unpredictable mild stress. Open-field test was performed to detect the behavior of rats and immunohistochemistry was used to observe the changes of p-CREB expression in hippocampus.
RESULTOn the 22nd day, the body weight and sacchar-intake of the depression model rats were all lower than those of the normal rats and the body weight and sacchar-intake of the rats treated by drugs were higher compared with model rats (P < 0.01). The depressive behavior in kaixinsan 4 g x kg(-1) group was significantly improved compared with the model group, the crossing scores and rearing scores were all increased (P < 0.01) and the expression of p-CREB in CA1, CA3 and DG in hippocampus was higher than that in the model group (P < 0.05 and P < 0.01).
CONCLUSIONKaixinsan might improve depressive behavior by increasing expression of p-CREB in CA1, CA3 and DG in hippocampus of the chronic stress rats.
