Effect of dongchong xiacao capsule on airway inflammation of asthmatic patients.
- Author:
Ning-qun WANG
1
;
Liang-duo JIANG
;
Xiao-mei ZHANG
;
Zong-xin LI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Asthma; drug therapy; immunology; Bronchitis; drug therapy; immunology; Capsules; Cordyceps; chemistry; Female; Humans; Immunoglobulin E; blood; Intercellular Adhesion Molecule-1; blood; Interferon-gamma; blood; Interleukin-4; blood; Male; Materia Medica; isolation & purification; pharmacology; Middle Aged; Th1 Cells; immunology; Th2 Cells; immunology
- From: China Journal of Chinese Materia Medica 2007;32(15):1566-1568
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of dongchong xiacao capsule on the airway inflammation of asthmatic patients and to explore the relevant mechanism of therapeutic effect of Dongchongxiacao capsule.
METHODSixty patients with moderate persistent asthma were randomized into the treatment group (n=30) and the control group (n=30). Inhaled corticosteroid and as-needed beta-agonist were used in the treatment group while this therapy plus dongchong xiacao capsule were used in the control group for two months. Serum IL-4, IFN-gamma, sICAM-1, MMP-9, IgG, IgE level were assessed at randomization and 2 months after randomization.
RESULTThe serum level of IgE, sICAM-1, IL-4 and MMP-9 of the treatment group was lowered to a greater degree than that of the control group (P < 0.05 or P < 0.01 ).
CONCLUSIONDongchong xiacao capsule can reduce the serum markers of airway inflammation, which suggests this therapy bares the anti-inflammation effects probably through regulating the balance of TH1/TH2, inhibiting the activity of adherence molecule and reducing IgE production. It may also have the effect of reversing airway remodeling, which needs further research to determine.
