Hypnotic effect of Chinese materia medica Cynanchum chinese in mice.
- Author:
Xiao-dong PENG
1
;
Qian-shun YAN
;
Rui WANG
;
Wei-dong YANG
;
Jian-zhong PENG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Central Nervous System; drug effects; physiology; Chloroform; Cynanchum; chemistry; Dose-Response Relationship, Drug; Drug Synergism; Drugs, Chinese Herbal; isolation & purification; pharmacology; toxicity; Female; Hypnotics and Sedatives; isolation & purification; pharmacology; Male; Mice; Mice, Inbred ICR; Motor Activity; drug effects; Pentobarbital; pharmacology; Plants, Medicinal; chemistry; Random Allocation; Sleep; drug effects; Water
- From: China Journal of Chinese Materia Medica 2007;32(17):1774-1776
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the central pharmacological effect of the water and chloroform-extract compounds from C. chinese in mice.
METHODThe independent activity test and the hypnotic synergism test by sub-threshold hypnotic dosage of pentobarbital were employed to evaluate the central pharmacological effect of the extract-compounds, and the minimal neurotoxicity was evaluated by the rotorod test.
RESULTthe extract-compounds exhibited significant dose-related inhibition effect of the spontaneous motor activity in mice after intraperitoneal administration. And the two extract-compounds promoted the hypnotic effect by sub-threshold hypnotic dosage administration of pentobarbital, and produced ED50 value of 2.36 g kg (-1) and 0.75 g kg(-1), respectively. Also, both extract-compounds showed no neurotoxicity in the experiment.
CONCLUSIONThe extract compounds from C. chinese showed inhibitional effect on CNS.
