Effects of volatie oil of Schizonepeta tenuifolia Briq herb and Saposhnikovia divaricata Schischke root on proinflammatory cytokine expression and regulation.
- Author:
Wei-hong GE
1
;
Jian-you GUO
;
Ying-jun SHEN
;
Min-li CHEN
;
Sen-lin SHI
;
Yu-huan HAN
;
Jie LIN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Anti-Inflammatory Agents; isolation & purification; pharmacology; Apiaceae; chemistry; Drug Combinations; Gene Expression Regulation; drug effects; Immunohistochemistry; Intercellular Adhesion Molecule-1; biosynthesis; Lamiaceae; chemistry; Lipopolysaccharides; Male; Oils, Volatile; isolation & purification; pharmacology; Oleic Acid; Plant Oils; isolation & purification; pharmacology; Plants, Medicinal; chemistry; RNA, Messenger; biosynthesis; genetics; Random Allocation; Rats; Rats, Wistar; Respiratory Distress Syndrome, Adult; chemically induced; metabolism; prevention & control; Transcription Factor RelA; biosynthesis; genetics
- From: China Journal of Chinese Materia Medica 2007;32(17):1777-1779
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effects of volatie oil of Schizonepeta tenuifolia Briq herb and Saposhnikovia divaricata Schischke root (OSS) on proinflammatory cytokine expression and regulation in rats.
METHODOA and LPS were injected intravenously to rats to develop acute lung injury (ALI). The rats were treated with OSS (45.19 microL kg(-1)). The pathological sections of lung tissue were prepared and observed in acute lung injury rats. The expression of nuclear factor-kappa B p65 (NF-kappaB p65), intercellar adhesion molecule CD54, and NF-kappaB p65 mRNA were determined in lung cells.
RESULTvolatie oil of Schizonepeta tenuifolia Briq herb and Saposhnikovia divaricata Schischke root significantly inhibited the expression of CD54, the activation of NF-kappaB p65, and the transcription of NF-kappaB p65 mRNA.
CONCLUSIONOSS can reduce the expression of CD54 and NF-kappaB p65 protein synthesis, which may be its anti-inflammatory molecular mechanisms.
