Effect of Rhizoma coptidis and Radix rehmanniae with different ratio on pharmacokinetics of berberine in rats.
- Author:
Xiao-qiang WANG
1
;
Ming-wei YANG
;
Fang-fang LIU
;
Fu-er LU
;
Li-jun XU
;
Xin ZOU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Area Under Curve; Berberine; blood; chemistry; pharmacokinetics; Biological Availability; Coptis; chemistry; Drug Combinations; Drugs, Chinese Herbal; chemistry; isolation & purification; pharmacokinetics; Male; Plant Roots; chemistry; Plants, Medicinal; chemistry; Random Allocation; Rats; Rats, Sprague-Dawley; Rehmannia; chemistry; Rhizome; chemistry
- From: China Journal of Chinese Materia Medica 2007;32(17):1795-1797
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effect of Rhizoma Coptidis and Radix Rehmanniae with the different ratio on the pharmacokinetics of berberine in rats.
METHOD24 rats were grouped to 4 groups randomly. Decoction, in which the proportion of Rhizoma Coptidis to Radix Rehmanniae is 1:0, 1:1, 1:4, 1:8 differently, was intragastrically given to the 4 groups. HPLC was used to determine concentration of berberine in serum. We adopted DAS 2.0 to analysis pharmacokinetic parameters of berberine.
RESULTThe concentration-time curves was all fitted to two-compartment model with a weight of 1/C2. Difference of 4groups in C(max), AUC(0-t), AUC(0-infinity), is significant (P <0.05).
CONCLUSIONRadix Rehmanniae of large dose can effectively enhance berberine's bioavailability in rats.
