Clinical study on a randomized, double-blind control of Shenwu gelatin capsule in treatment of mild cognitive impairment.
- Author:
Jian ZHONG
1
;
Jin-zhou TIAN
;
Ai-hua ZHU
;
Cheng-zhi YANG
Author Information
- Publication Type:Journal Article
- MeSH: Acorus; chemistry; Aged; Capsules; Cognition; drug effects; Cognition Disorders; drug therapy; physiopathology; psychology; Double-Blind Method; Drug Combinations; Drugs, Chinese Herbal; administration & dosage; isolation & purification; therapeutic use; Female; Gelatin; Humans; Male; Memory; drug effects; Middle Aged; Panax; chemistry; Phytotherapy; Plants, Medicinal; chemistry; Polygonum; chemistry; Treatment Outcome
- From: China Journal of Chinese Materia Medica 2007;32(17):1800-1803
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the effectiveness of Shenwu gelatin capsule (compound Chinese ginseng and fleeceflower root etc) in the treatment on senile mild cognitive impairment.
METHOD166 patients meeting criteria for mild cognitive impairment were selected from patients in Dongzhimen Hospital and were randomly assigned into a treatment group (n = 83 cases), given 5 capsules of Shenwu gelatin capsule, and a positive control group (n = 83 cases) , given 2 capsules of aniracetam with 3 placebo capsules. All subjects took this medication 3 times a day for 3 months, double-blind and double-moulding control were used in this study. At a baseline and end (three months later), all subjects were assessed using a battery consisting of MMSE and clinical memory scale (CMS).
RESULTBoth Shenwu gelatin capsule and aniracetam can remarkably increase the score of memory quotient (MQ), P < 0. 01. They have the similarly effectiveness, there are no statistical difference between the two groups in effectiveness of increasing memory scores.
CONCLUSIONShenwu gelatin capsule has certain effects on mild cognitive impairment.
