In vivo/in vitro evaluation of Kangfuxin colon targeting capsules.
- Author:
Xue-lan QIU
1
;
Ming YANG
;
Xing-liang XIE
;
Juan LAI
;
Si-wei CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Capsules; Colon; diagnostic imaging; metabolism; Delayed-Action Preparations; chemistry; Drug Carriers; Drug Delivery Systems; Female; Humans; Hydrogen-Ion Concentration; Male; Materia Medica; administration & dosage; isolation & purification; pharmacokinetics; Periplaneta; chemistry; Polygalacturonase; chemistry; Radiography
- From: China Journal of Chinese Materia Medica 2007;32(16):1644-1647
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the release in fixed position of pH-dependent and enzyme-dependent Kangfuxin colon targeting capsules in vivo and in vitro.
METHODThe dissolution was tested in vitro and X-ray radiography was used for the evaluation in vivo.
RESULTAfter two hours pH-dependent colon targeting in man-made colon fluid, medicine release in fixed position on the whole, colon loc-release. Add enzyme into man-made colon, when enzyme-dependent colon targeting in it, then medicine release quickly, mainly release in fixed position; The conveying time in vivo of pH-dependent and enzyme-dependent capsules have big individuality difference. In the experiment, disintegration is stabilize among individuales, between 2.0-3.5 hours.
CONCLUSIONKangfuxin colon targeting capsules of two principles all release in fixed position to achieve the goal.
