Effects of sapindoside on blood pressure and vasoactive substance in renovascular hypertension rat.
- Author:
Wei-sheng WANG
1
;
Zi-jiang LONG
;
Ling ZHANG
;
Hai BIAN
;
Liang WANG
;
Ming CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Aldosterone; blood; Angiotensin II; blood; Animals; Antihypertensive Agents; isolation & purification; pharmacology; Blood Pressure; drug effects; Drugs, Chinese Herbal; isolation & purification; pharmacology; Endothelins; blood; Female; Hypertension, Renovascular; blood; physiopathology; Male; Nitric Oxide; blood; Oleanolic Acid; analogs & derivatives; isolation & purification; pharmacology; Plants, Medicinal; chemistry; Rats; Rats, Sprague-Dawley; Sapindus; chemistry; Saponins; isolation & purification; pharmacology
- From: China Journal of Chinese Materia Medica 2007;32(16):1703-1705
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effects of sapindoside on blood pressure, Ang II, Ald, ET in the blood plasma and NO in the serum in renovascular hypertension rat.
METHODThe 2K1C (2 kidney 1 clap) hypertensive model rats were used and drugs had been given by ig. for 5 weeks. The blood pressure was measured at the 1, 3, 7, 14, 21, 28, 35 day after drug. At the end of 5th weeks, the Ang II, Ald, ET in the blood plasma and NO in the serum were measured.
RESULTSapindoside (H, M and L) by ig. for 5 weeks could significantly lower the blood pressure, increase the levels of NO in the serum, reduce the concentration of Ang II, Ald, ET in the blood plasma.
CONCLUSIONSapindoside plays an important role in decreasing the blood pressure of renovascular hypertension rat.
