Study on the genetic association between the polymorphism of cytosolic phospholipase A2 family genes and schizophrenia.
- Author:
Qiong YU
1
;
Jie-Ping SHI
;
Chang-Gui KOU
;
Xiang-Fei MENG
;
Ya-Qin YU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Asian Continental Ancestry Group; genetics; China; epidemiology; Female; Gene Frequency; genetics; Genetic Predisposition to Disease; genetics; Genotype; Haplotypes; genetics; Humans; Male; Phospholipases A2, Cytosolic; genetics; Polymorphism, Single Nucleotide; genetics; Schizophrenia; epidemiology; genetics; Young Adult
- From: Chinese Journal of Epidemiology 2008;29(2):173-176
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the genetic association between the polymorphism of cytosolic phospholipase A2 (cPLA2) family genes and schizophrenia in the North Han Chinese.
METHODSMethod of polymerase chain reaction-based ligase detection reaction (PCR-LDR) was applied to genotype 10 single nucleotide polymorphisms (SNPs) of cPLA2 family genes among 201 pedigrees consisting of fathers, mothers and affected offsprings with schizophrenia. Haplotype relative risk (HRR) test, transmission disequilibrium test (TDT), haplotype transmission analysis and multiple locus analysis were conducted to analyze the genotyping data.
RESULTSThe genotypic frequency of cPLA2 gene did not deviate from Hardy-Weinberg equilibrium in both case and control groups. HRR and TDT showed that the 10 SNPs were not associated with schizophrenia (P > 0.05). Analysis for haplotype transmission showed that no haplotype systems was associated with schizophrenia (P > 0.05). Results from COA and COG tests showed a disease association for the rs2162886-rs1668589, rs891014-rs1668589 and rs2307279-rs7542180 combinations (chi2 = 6.913, P = 0.032; chi2 = 8.393, P = 0.015; chi2 = 8.447, P = 0.038).
CONCLUSIONMany loci in the cPLA2 family genes were associated with schizophrenic.
