Effect of NaFeEDTA on hemoglobin level in iron deficient population: a systematic review.
- Author:
Bo WANG
1
;
Si-yan ZHAN
;
Yin-yin XIA
;
Li-ming LI
Author Information
- Publication Type:Journal Article
- MeSH: Anemia, Iron-Deficiency; blood; drug therapy; metabolism; Edetic Acid; therapeutic use; Ferric Compounds; therapeutic use; Hemoglobins; metabolism; Humans; Iron Chelating Agents; therapeutic use
- From:Chinese Journal of Epidemiology 2008;29(1):65-70
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the effect of NaFeEDTA on hemoglobin level in iron deficient population.
METHODSComprehensive literature retrieval was performed via searching electronic databases, hand searching bibliographies of books and relevant journals, collecting grey literatures, looking into conference abstracts, contacting fields experts and reviewing references and citations. Criteria from Cochrane EPOC review group were used to assess the quality of included studies. Generic inverse variance method was used to undertake meta-analysis.
RESULTSThe pooled estimate for hemoglobin level (weighted mean difference) was 12.14 g/L (95% CI: 5.60-18.69; P < 0.001). Subgroup analysis indicated that lower baseline hemoglobin level and higher dose for intervention were associated to greater increase in hemoglobin level.
CONCLUSIONThis systematic review indicated that NaFeEDTA improved hemoglobin significantly in iron deficient population.
