Study on the value of Helieobacter pylori (H. pylori) stool antigen immunocard STAT in the diagnosis of H. pylori infection: a meta-analysis.
- Author:
Wan-dong HONG
1
;
Qi-huai ZHU
;
Xiang-rong CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Antigens, Bacterial; immunology; Feces; microbiology; Helicobacter Infections; diagnosis; immunology; Helicobacter pylori; immunology; isolation & purification; pathogenicity; Reagent Kits, Diagnostic; Sensitivity and Specificity
- From: Chinese Journal of Epidemiology 2008;29(1):71-74
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the accuracy of the Helicobacter pylori (H. pylori) stool antigen (HpSA) test and ImmunoCard STAT HpSA in the primary diagnosis of H. pylori infection.
METHODSWe searched Medline (1966-2007.4), EMbase (1985-2007.4), Chinese Journals Full-text Database (CJFD) (1994-2007) etc. to identify Clinical Trials of ImmunoCard STAT HpSA for the primary diagnosis of H. pylori infection. Meta-analysis was conducted using the method recommended by The Cochrane Collaboration Center.
RESULTSEleven trials were included with pooled sensitivity, pooled specificity as 0.93 (95% CI: 0.91-0.94), 0.93 (95% CI: 0.90- 0.95), respectively. Pooled positive likelihood ratio and pooled negative likelihood ratio were 12.01 (95% CI: 8.90-16.19), 0.08 (95% CI: 0.07-0.11), respectively with the pooled diagnostic odds ratio as 160.14(95% CI :100.43-255.34). The area under the summary receiver operating characteristic (SROC) was 0.974 +/- 0.005.
CONCLUSIONImmunoCard STAT HpSA appeared to be an accurate non-invasive method for the initial diagnosis of H. pylori infection.
