Study on Xinyueshu spray drying assisted with copovidone and its effect on powder property.
- Author:
Yan-Rong JIANG
;
Zhen-Hai ZHANG
;
Dong-Mei DING
;
Hong-Mei YAN
;
Shao-Ying HU
;
Xiao-Bin JIA
- Publication Type:Journal Article
- MeSH:
Absorption;
Desiccation;
methods;
Drug Compounding;
methods;
Drugs, Chinese Herbal;
chemistry;
Porosity;
Powders;
Pyrrolidines;
chemistry;
Vinyl Compounds;
chemistry;
Wettability
- From:
China Journal of Chinese Materia Medica
2013;38(23):4067-4070
- CountryChina
- Language:Chinese
-
Abstract:
To study the application characteristics of copovidone (PVP-S630) in Xinyueshu extracts during the spray drying process, and its effect on such pharmaceutical properties as micromeritics and drug release behavior. PVP-S630 was added into Xinyueshu extracts to study on the spray drying, the effect of different dosages of PVP-S630 against the wall sticking effect of the spray drying, as well as the power property of Xinyueshu spray drying power and the dissolution in vitro behavior of the effective component of hyperoside. The results showed that PVP-S630 revealed a significant anti-wall sticking effect, with no notable change in the grain size of the spray drying power, increase in the fluidity, improvement in the moisture absorption and remarkable rise in the dissolution in vitro behavior of hyperoside. It was worth further studying the application of PVP-S630 in spray drying power of traditional Chinese medicine.
